Newport Biotechnology Consultants

Multiplexing Brings HTS to Higher Level

jmorrow — Fri, 15 Jul 2011 17:54:20 +0000

Multiplex assays are based on single analyte tests or low-to-midplex procedures that typically predate the rise of their multiplex versions. They may include vast numbers of analytes in a single assay and require specialized technologies or miniaturization to achieve a higher degree of parallelization.

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Small Molecular Simplicity Gives Them Staying Power

jmorrow — Wed, 15 Jun 2011 17:39:24 +0000

There is a profound association between cancer and inflammatory processes, according to Raffaella Sordella, Ph.D., assistant professor at Cold Spring Harbor Laboratory. Dr. Sordella was a keynote speaker at CHI’s recent conference on drug discovery chemistry.

Discussions at the meeting about small molecule approaches to anti-inflammatory therapies devoted considerable time to the link between malignancy and inflammation.

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Shaking Up Downstream Processing

jmorrow — Fri, 01 Apr 2011 17:44:03 +0000

Liverpool is best known as the scruffy British industrial city that gave the Beatles their start back in the 60s, but it is recognized today for reinventing its image as a home to an expanding biotech presence. SAFC (www.safcglobal.com) and Sartorius Stedim (www.sartorius-stedim.com) recent “Downstream Processing Day” seminar was held in the city and brought together investigators from a number of companies, many with facilities at the Liverpool Science Park.

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Cancer Marker Pursuit Heats Up

jmorrow — Tue, 15 Mar 2011 19:20:50 +0000

The search for cancer biomarkers has proven to be a long, frustrating, and mainly fruitless exercise. Despite the substantial investment, no new markers suitable for large-scale screening protocols have achieved FDA approval. Yet, improvements in investigative tools, as well as innovative computer analysis, offer hope that the situation may be changing, and newly characterized candidates may prove to be clinically useful.

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Strategies to Advance mAb Production

jmorrow — Tue, 01 Mar 2011 17:33:13 +0000

While approval of new therapeutic antibodies has not progressed as rapidly as was forecast 10 years ago, new products are moving through the pipeline. As always, bioprocessing, critical to antibody manufacture, is a key factor in the cost and efficiency of production.

Interviews with company officials and researchers engaged in bioprocessing showed how novel approaches to these challenges are moving the industry forward.

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Making Strides in Protein Characterization

jmorrow — Tue, 01 Feb 2011 17:49:22 +0000

The bioprocessing industry continues to transform and reinvent itself as a range of new technologies is introduced and adopted. The sequencing of the human genome has made available a wealth of targets for drug development, translating into a demand for appropriate biotherapeutics. Moreover, the expiration of patent protection for many biologics is fueling increasing interest in biosimilars.

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Novel Methods Expedite Nucleic Acid Sample Prep

jmorrow — Sat, 01 Jan 2011 03:23:50 +0000

Recent developments in genomic identification using microarray technologies are infiltrating the fields of forensics, diagnostics, and sample identification. They include a combination of new hardware designs and innovative approaches to sample processing. In addition, microfluidics and miniaturization are emerging as key components of powerful new multiplexing platforms. Knowing how to reduce risks is vital to avoiding legal trouble in this still-emerging field.

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Microarray technology to the fore

jmorrow — Mon, 01 Nov 2010 20:19:38 +0000

Innovative and reconfigured platforms help researchers maximize genomic studies

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Innovative Protein-Expression Systems

jmorrow — Mon, 06 Sep 2010 18:43:11 +0000

There has been a maturation of the bioprocessing industry as companies have moved away from a focus on anticancer biologics toward a more diversified portfolio of pharmacological agents.

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LC/MS Solidifying Key Role in Clinical Labs

jmorrow — Mon, 06 Sep 2010 18:42:53 +0000

Gas or liquid chromatography combined with mass spectrometry is widely recognized as a versatile and powerful technique for the investigation of complex chemical mixtures. A state-of-the-art accounting of progress in this area took place recently in Hong Kong at the conference on “New Horizons in Clinical
Chemistry.”