Multiplexing Brings HTS to Higher Level
July 15, 2011
Multiplex assays are based on single analyte tests or low-to-midplex procedures that typically predate the rise of their multiplex versions. They may include vast numbers of analytes in a single assay and require specialized technologies or miniaturization to achieve a higher degree of parallelization.
Read the full article
Small Molecular Simplicity Gives Them Staying Power
June 15, 2011
There is a profound association between cancer and inflammatory processes, according to Raffaella Sordella, Ph.D., assistant professor at Cold Spring Harbor Laboratory. Dr. Sordella was a keynote speaker at CHI’s recent conference on drug discovery chemistry.
Discussions at the meeting about small molecule approaches to anti-inflammatory therapies devoted considerable time to the link between malignancy and inflammation.
Read the full article
Shaking Up Downstream Processing
April 1, 2011
Liverpool is best known as the scruffy British industrial city that gave the Beatles their start back in the 60s, but it is recognized today for reinventing its image as a home to an expanding biotech presence. SAFC (www.safcglobal.com) and Sartorius Stedim (www.sartorius-stedim.com) recent “Downstream Processing Day” seminar was held in the city and brought together investigators from a number of companies, many with facilities at the Liverpool Science Park.
Read the full article
Cancer Marker Pursuit Heats Up
March 15, 2011
The search for cancer biomarkers has proven to be a long, frustrating, and mainly fruitless exercise. Despite the substantial investment, no new markers suitable for large-scale screening protocols have achieved FDA approval. Yet, improvements in investigative tools, as well as innovative computer analysis, offer hope that the situation may be changing, and newly characterized candidates may prove to be clinically useful.
Read the full article
Strategies to Advance mAb Production
March 1, 2011
While approval of new therapeutic antibodies has not progressed as rapidly as was forecast 10 years ago, new products are moving through the pipeline. As always, bioprocessing, critical to antibody manufacture, is a key factor in the cost and efficiency of production.
Interviews with company officials and researchers engaged in bioprocessing showed how novel approaches to these challenges are moving the industry forward.
Read the full article
Making Strides in Protein Characterization
February 1, 2011
The bioprocessing industry continues to transform and reinvent itself as a range of new technologies is introduced and adopted. The sequencing of the human genome has made available a wealth of targets for drug development, translating into a demand for appropriate biotherapeutics. Moreover, the expiration of patent protection for many biologics is fueling increasing interest in biosimilars.
Read the full article
Novel Methods Expedite Nucleic Acid Sample Prep
January 1, 2011
Recent developments in genomic identification using microarray technologies are infiltrating the fields of forensics, diagnostics, and sample identification. They include a combination of new hardware designs and innovative approaches to sample processing. In addition, microfluidics and miniaturization are emerging as key components of powerful new multiplexing platforms. Knowing how to reduce risks is vital to avoiding legal trouble in this still-emerging field.